Therapeutic use of this enzyme is as a facilitating factor in the release of toxins and vaccine injected under the skin. Hyaluronidase in snake and insect venom is thought to function as a “spreading factor” by degrading the host hyaluronic acid, thus allowing the spread of toxin ( 12, 13). agalactiae ( 9), Pseudomonas aeruginosa ( 10) and Staphylococcus aureus ( 11). pneumoniae ( 6), Enterococcus ( 7), Clostridium perfringens ( 8), S. The catalytic mechanism of hyaluronidase is unknown ( 4) the structure and biological activity of hyaluronidase have been intensively studied in different microorganisms such as Streptococcus pyogenes ( 5), S. Hyaluronidase is produced in both prokaryotic and eukaryotic cells ( 2, 3). The function of this enzyme is increasing the permeability of tissue to fluids ( 1). Hyaluronidases are enzymes that hydrolyze hyaluronic acid (HA) to N-acetyl-D-glucosamine (GlcNAc) and D-glucuronic acid (GlcA) in the body. Hyaluronidase Optimization of Expression Enzymatic Activity 1. In addition, applications of bioinformatics software would facilitate the production of a smaller protein with same antigenic properties and enzymatic activity. It can be suggested to use it for medical purposes. pyogenes has a considerable enzymatic activity. The results showed that an antigenic fragment of the recombinant hyaluronidase protein from S.
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